April 27, 2021 9:45 a.m.–4:15 p.m. CEST

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COMSOL Day: Biomedical Applications

See what is possible with multiphysics simulation

Join fellow engineers and simulation specialists to learn about multiphysics simulations in applications that involve biomedical processes and devices.

We welcome both experienced COMSOL Multiphysics® users and those who are new to the COMSOL® software to attend COMSOL Day. The sessions will focus on modeling techniques in the respective application areas, and you will learn about the software features and best practices from applications engineers. Keynote speakers from industries based on or reliant on such devices will provide perspective on the importance of simulation to these applications.

Detailed schedule will follow soon. Register for free today and stay tuned!

Schedule

09:45
Registration
10:00
Welcoming Remarks
10:15

Simulation helps experts and nonexperts alike better understand and optimize medical devices and biomedical processes. As a result, better implants, testing procedures, imaging devices, sensors, treatment methods, and much more have been developed faster and more efficiently as simulation has become more widespread.

However, significant bottlenecks have arisen and are often not dependent on the simulation software's ability to represent the complex and coupled physics prevalent in biomedical applications, but rather the limited number of skilled users who can create and run the desired models. For this reason, the trend is to make simulation possible for all involved in the development process to participate through the use and distribution of specialized simulation apps.

11:00
Modeling Biosensors

Biosensors exploit biological components in the detection of a chemical substance. For example, enzymes may be used to quantify contaminants, such as pesticides or antibiotics. In the medical and agrifood fields, antibodies may be used in biosensors to measure antigens. During an analysis, the ligand sees its modified properties and emits a physiochemical signal, which is transformed by a transducer into an analyzable signal.

In this presentation, we will discuss how the COMSOL Multiphysics® software can be used to model biosensor devices. We will demonstrate a model for the adsorption of antigens in aqueous solutions on an array of micropillars and examine the impact of design parameters, such as pillar diameter, grid spacing, and inlet velocity, on the detection capabilities.

Tech Café: Creating Apps

Simulation apps enable you to expand your modeling and give more control to your colleagues who require simulations for their designs and processes. You can create user-specific modeling environments that are best suited to their simulation needs while also being easy enough for them to use, even if they are not modeling experts. During this Tech Café, you can discuss how best to develop simulation apps with COMSOL engineers, who will also be answering your specific questions.

11:45

Laurent Drazek, bioMérieux

The rise of COVID-19 has shown the importance of in vitro diagnostics (IVD) solutions for the monitoring and management of pandemics. In this context, a syndromic approach to diagnostic testing for infectious diseases has become increasingly pertinent and consequential. BioMérieux's BioFire FilmArray, a multiplex polymerase chain reaction (PCR) system for in vitro diagnostics, achieves this aim with a full respiratory panel, including SARS-CoV-2 and many other pathogens that cause symptoms common to COVID-19. BioFire FilmArray panels extend to many more syndromes, from gastrointestinal diseases to identification of pathogens in positive blood cultures. A careful optimization of several system parameters is required to achieve the desired sensitivity and specificity for each pathogen. For instance, given the vulnerability of PCR efficiency to small changes in temperature, thermal modeling can play an invaluable role in this process by providing a full, precise, and reliable thermal profile of the fluid containing the PCR reaction, as the fluid is otherwise inaccessible to traditional thermal measurement devices.

This presentation will show how FEM-based numerical simulations with COMSOL Multiphysics® can support the development and maintenance of highly sensitive systems dedicated to IVD.

12:15
Break for Lunch
Introduction to COMSOL Multiphysics® for New Users

Learn the fundamental workflow of COMSOL Multiphysics®. This introductory demonstration will show you all of the key modeling steps, including geometry creation, setting up physics, meshing, solving, and postprocessing.

13:15
Acoustics-Based Applications

Acoustics-based methods and devices play an important role in medical technology. Applications range from diagnostic and therapeutic ultrasound procedures to hearing aids. In this session, you will learn more about the possibilities and challenges that arise in such applications, such as nonlinearities and thermoviscous effects, which must be taken into account for realistic models, analyses, and to find optimized design parameters and operating conditions.

Tech Café: Bioheating

Learn and discuss how to model and simulate electromagnetic heating problems in biomaterials using the Heat Transfer Module, AC/DC Module, and RF Module within the COMSOL® software environment.

14:00

Thomas Clavet, EMC3 Consulting

Acoustic waves in the ultrasonic range are widely used in many industries, including MedTech. For instance, echography is a well-known medical imaging technique that is often prescribed to diagnose an illness or health issue.

In addition to diagnostics, ultrasound can also provide a noninvasive way to treat a condition. Focused ultrasound (FUS) devices have become a common choice to kill cancerous tumors in the prostate, breast, pancreas, liver, and brain, but other conditions also take advantage of focused ultrasound, such as neurodegenerative diseases and glaucoma. Research in the field is very important and could lead to disruptive technologies and novel treatments in years to come.

High-intensity focused ultrasound (HIFU) ablation tools are designed to produce a localized elevation of temperature and necrosis of biological tissues. Simulating the acoustics and heat transfer phenomena involved in such tools allows engineers and researchers to select the combination of parameters that will deliver the right amount of energy in the targeted zone and limit the damage to the surrounding healthy tissues. There are numerous parameters, including the size of the transducer that transmits the ultrasound, the frequency of the signal, and the duration of the treatment.

Challenges remain as well, related to the knowledge of acoustics and thermal properties of tissues, and the nonlinear effects that happen at these high frequencies and amplitudes. Thus, there is still a long way to go before having a patient-specific treatment planning simulator, but the COMSOL® software would be a solution of choice to try to reach this goal.

In this presentation, Thomas Clavet from EMC3 Consulting will discuss how HIFU can be produced and key points about how to model this multiphysics problem.

14:30
Modeling Electromagnetic Medical Devices

RF-based electromagnetic ablation, cardiac pacemakers, and magnetic resonance imaging systems are all examples of biomedical device applications that rely on electromagnetic interactions with biological tissue. Multiphysics simulation can help to better understand, develop, improve, and optimize these applications. In this session, you will learn how such applications can be set up and applied to real-life cases through the use of both predefined modeling interfaces and the ability to manipulate the underlying modeling strategies and parameters provided by these interfaces.

Tech Café: Soft-Tissue Biomechanics

In order to learn more about the mechanical behavior of soft tissues by means of simulation, various aspects of the tissue have to be considered, which makes such applications very challenging from a modeling point of view. In addition to the nonlinear structural material behavior, which also often has anisotropic and heterogeneous parameters, the fluid–structure interactions between, for example, non-Newtonian blood and veins, are often critical.

In this Tech Café, you will be able to discuss these aspects of biomechanics simulation with COMSOL technical staff and ask them questions specific to your applications.

15:15
Invited Speaker
16:00
Concluding Remarks

COMSOL Speakers

Phillip Oberdorfer
COMSOL
Phillip Oberdorfer is a technical marketing manager at Comsol Multiphysics GmbH. He helps produce webinar and technical content. Previously, he worked as an applications manager in technical support. Phillip received his PhD from the University of Göttingen, where he used COMSOL Multiphysics for a geothermal energy research project.
Thorsten Koch
COMSOL
Thorsten Koch is the managing director of Comsol Multiphysics GmbH. There, he worked as an applications engineer and was a member of the development team. He holds degrees in physics and applied mathematics, completing his PhD studies on 3D contractility measurements of living cells at the University of Erlangen-Nuremberg.
Mads J. Herring Jensen
Technology Manager, Acoustics
Mads Herring Jensen joined COMSOL in 2011 and is the technology manager for the acoustics products. Mads has a PhD in computational fluid dynamics from the Technical University of Denmark. Before joining COMSOL, he worked in the hearing aid industry for five years as an acoustic finite element expert.
Johannes Schumacher
COMSOL
Johannes Schumacher works as an application engineer at Comsol Multiphysics GmbH. He studied chemistry at the Friedrich-Alexander-University Erlangen-Nürnberg, where he investigated platinum deposition in nanoporous alumina. For his doctorate at the Georg-August-University Göttingen, he worked with lipid bilayers and developed nanoscale porous support structures for cell membrane models.
Lars Dammann
Applications Engineer
Lars Dammann has been an applications engineer at Comsol Multiphysics GmbH since 2016. He obtained his MSc in experimental solid-state physics at the University of Göttingen, where he studied the interaction of electrons and optical near fields using an ultrafast, low-energy electron diffraction experiment.
Ad van der Linden
COMSOL
Ad van der Linden works as an applications engineer and joined Comsol Multiphysics GmbH in 2008. Prior, he studied applied physics at the Technical University Delft in the Netherlands. He has more than 20 years of experience in electromagnetic applications combined with numerical simulations.
Andreas Bick
COMSOL
Andreas Bick is an applications engineer at Comsol Multiphysics GmbH. He holds a PhD in physics from the University of Hamburg, where he studied ultracold quantum gases in noncubic optical lattices, hybrid quantum systems, optical resonators, and micromechanical systems.
Ross Hubble
COMSOL
Ross Hubble works as an applications engineer at COMSOL UK. He graduated from the University of Cambridge in 2010 with an MEng in chemical engineering and then went on to carry out his PhD investigating carbon oxide hydrogenation reactions.
Melanie Pfaffe
COMSOL
Melanie Pfaffe is an account manager at Comsol Multiphysics GmbH. In 2011, she earned her PhD from the Humboldt University of Berlin, where she studied computer-aided theoretical chemistry.
Thomas Englisch
COMSOL
Thomas Englisch works as an account manager at Comsol Multiphysics GmbH. As a research assistant at the Bielefeld University of Applied Sciences, he dealt with numerical simulation in research and teaching. During his physics studies, he specialized in computer-oriented theoretical physics.

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COMSOL Day Details

Location

This event will take place online.

Local Start Time:
April 27, 2021 | 9:45 a.m. CEST (UTC+02:00)
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Invited Speakers

Laurent Drazek
bioMérieux

Laurent Drazek has been in charge of the modeling and simulation of systems in the Data Science department at bioMérieux since 2018, after 14 years as a research engineer within the R&D System department. He graduated as an engineer (INP Grenoble) in 2001 and holds a MSc degree in physics (Université Grenoble Alpes). He earned a PhD in physics from Université Grenoble Alpes in 2004. His PhD work involved the design and mathematical modeling of a system producing a complex 3D flow dedicated to biological applications. The modeling applications at bioMérieux extend from immunoassays and microbiology to molecular biology systems dedicated to in vitro diagnostics (IVD).

Thomas Clavet
EMC3 Consulting

Thomas Clavet founded EMC3 Consulting in 2014 to support companies (including SMEs, major industrial groups, and research laboratories) in their use of digital simulation for acoustics, thermal, mechanical, and overall multiphysics applications. Thomas since specialized in piezoelectric, ultrasonic, and vibration simulation that can be used in motors, sensors, flowmeters, haptics, NDT systems, and medical devices such as the FUS probes developed with his customers.

Prior to becoming a COMSOL Certified Consultant, Thomas was a mechanical engineer in the energy industry and an application engineer at COMSOL in the UK and Ireland. He is an Arts et Métiers ParisTech engineer and holds a master's degree in mechanics and numerical methods from the Royal Polytechnic Institute (KTH) in Stockholm, Sweden.